Amisha Patel was born on 9 June 1976. She was born in Mumbai. She is an alumna of the Cathedral and John Connon School where she was head girl for the academic year 1992-1993.
Amisha Patel is the daughter of Amit Patel and Asha Patel, sister of Ashmit Patel and the granddaughter of the famous Indian lawyer Rajni Patel. She received a degree in Economics from Tufts University, Medford, Massachusetts, US. She also studied classical Indian Bharatnatyam dance. Her name Amisha was derived from the first three letters of her father's name Amit and the last three letters of her mother's name Asha. Her brother Ashmit's name was also derived similarly first three letters of his mother's name Asha and the last three letters of his father's name Amit.
After returning to India she joined Satyadev Dubey's theatre group and began acting in plays, but only after receiving permission from her conservative parents.
She caught the eye of Bollywood director Rakesh Roshan at a Mumbai party. He signed her to appear with his son, Hrithik Roshan, in his next film project. Soon Amisha made her acting debut with Rakesh Roshan's 'Kaho Naa... Pyaar Hai'. The film was the biggest hit of the year, and made her a star overnight